Here, we have identified a redoxmediated signalling mechanism directly regulating TDP43. Using in vitro and cellbased studies, we demonstrate that oxidative stress promotes TDP43 crosslinking via cysteine oxidation and disulphide bond formation leading to decreased TDP43 solubility. Biochemical analysis identified several cysteine residues located within and adjacent to the second RNArecognition motif that contribute to both intra and intermolecular interactions, supporting TDP43 as a target of redox signalling.They will play like the better team this week. Pick: Jaguars 4. Jaguars 20, Colts 13..

Umpteen fresh installs later figured out there was a little scratch on the xp disc, got another disc and that sorted it. A couple of weeks later decided to have another look at old computer, reset cmos, reinstalled and i'm writing this post on it, all updated and antivirused etc, not done any extensive testing but after nearly 24 hrs everything looking good. Looks like the problem