2010 saw the arrival of Darksiders. You could argue it borrowed heavily from God of War and Zelda's playbooks but there's no denying its quality. THQ gave the studio an almost unheard of fouryears to develop the game and its polish shows.IgG and IgM antibodies binding to the surface of a neuronal cell line were found in 70 of sera from patients with secondary progressive (SP)MS and in 25 of sera from patients with relapsingremitting (RR)MS.42 This finding may indicate the spreading of autoimmunity to neuronal antigens as a consequence of CNS tissue damage, and the expansion of pathology from moderate to marked neuroaxonal loss associated with a transition from RR to SPMS course.Axolemmaenriched fractions Antibodies to axolemmaenriched fractions (AEF) of the CNS are also present in CSF and sera of MS patients.16 These antibodies damage neurites and prevent neuronal outgrowth in vitro. The production of antiaxolemma and antimyelin IgGs appears to be independent. Based on these obser