Both FUS and TDP43 are DNA and RNAbinding proteins that shuttle continuously between the nucleus and cytoplasm (Zinszner et al, 1997b; Ayala et al, 2008) and are involved in multiple steps of gene expression, such as transcriptional regulation, premRNA splicing and microRNA processing (Buratti and Baralle, 2008; LagierTourenne and Cleveland, 2009). In addition, FUS has been implicated in mRNA export and mRNA transport to neuronal dendrites (Fujii and Takumi, 2005; Fujii et al, 2005). Although FUS and TDP43 normally reside and function predominantly in the nucleus, pathological FUS and TDP43 inclusions are mostly observed in the cytosol, and inclusionbearing cells often show a reduction of nuclear staining (Arai et al, 2006; Neumann et al, 2006, 2009a; Kwiatkowski et al, 2009; Vance et al, 2009).Are you ready for some football? The Arizona Cardinals are back for another season, and everything is allnew. The team has the eyes of the NFL on them with recent developments being talked a