IgG and IgM antibodies binding to the surface of a neuronal cell line were found in 70 of sera from patients with secondary progressive (SP)MS and in 25 of sera from patients with relapsingremitting (RR)MS.42 This finding may indicate the spreading of autoimmunity to neuronal antigens as a consequence of CNS tissue damage, and the expansion of pathology from moderate to marked neuroaxonal loss associated with a transition from RR to SPMS course.Axolemmaenriched fractions Antibodies to axolemmaenriched fractions (AEF) of the CNS are also present in CSF and sera of MS patients.16 These antibodies damage neurites and prevent neuronal outgrowth in vitro. The production of antiaxolemma and antimyelin IgGs appears to be independent. Based on these observations, the use of antiaxolemma IgGs as markers of axonal damage was proposed.55Neurofascin One of the targets in antibodymediated axonal injury is a celladhesion molecule neurofascin.5. HARRISON WASN'T A FACTOR: A lot of the attention wa