We present evidence that Notch processing was required for the activation of the signal transduction cascade. However, dominantnegative (DN) and RNA interference approaches, as well as the use of a deletion mutant, showed that NIC activity did not require CBF1 transcription. Reduced nuclear retention did not inhibit the antiapoptotic activity of NIC.As a congressman, Kemp was one of the few members of the House along with Democratic Speaker Thomas P. "Tip" O'Neill to have national name recognition. With his Kennedyesque hairstyle, boyish good looks, unbounded enthusiasm and raspy voice, Kemp seemed a natural to bring new energy and interest to the Republican Party when he ran with Sen.

By the end of his junior year, the competition to sign the state's best player had grown fierce. During an open college tryout at that summer, Orlovsky agreed to throw a few passes to Milford receivers. Of course, it didn't take long before Orlovsky became the focus of the auditi